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运动疗法联合塞来昔布对膝关节韧带损伤 患者关节功能的影响
Effect of exercise therapy combined with celecoxib on joint function of patients with knee ligament injury
收稿日期:2022-05-23  修订日期:2022-05-31
DOI:
关键词:  运动疗法  塞来昔布  骨关节韧带损伤  关节功能
Key Words:Exercise therapy  Celecoxib  Bone joint ligament injury  Joint function
基金项目:浙江省医药卫生科技计划项目(2021KY939)
作者单位
郑思化 杭州市西溪医院骨科浙江杭州 310023 
赵学正 杭州市西溪医院骨科浙江杭州 310023 
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摘要:目的 探讨运动疗法联合塞来昔布对膝关节韧带损伤患者关节功能的影响。方法 选取2018年11月至2021年11月杭州市西溪医院收治的117例膝关节韧带损伤患者,采用随机数字表法将其分为运动组(38例)、药物组(39例)和联合组(40例)。运动组患者行运动疗法治疗,药物组患者使用塞来昔布治疗,联合组患者给予塞来昔布联合运动疗法治疗。比较三组患者的临床疗效、不良反应发生情况及治疗前后关节肿胀、疼痛程度、关节活动度及功能变化。结果 治疗后,三组患者的肿胀值、视觉模拟评分法(visual analogue scale,VAS)评分均显著低于本组治疗前,内旋、外旋、屈伸活动度均显著大于本组治疗前,国际膝关节文献委员会(International Knee Documentation Committee,IKDC)评分、Lysholm评分均显著高于本组治疗前(P<0.05);联合组患者的肿胀值、VAS评分均显著低于运动组和药物组,内旋、外旋、屈伸活动度均显著大于运动组和药物组,IKDC评分、Lysholm评分均显著高于运动组和药物组(P<0.05)。联合组患者的治疗总有效率显著高于运动组和药物组(P<0.05)。三组患者的不良反应总发生率比较差异无统计学意义(P>0.05)。结论 运动疗法联合塞来昔布可显著缓解膝关节韧带损伤患者的疼痛、肿胀,改善关节活动度及关节功能,促进患者疾病恢复。
Abstract:Objective To explore the effect of exercise therapy combined with celecoxib on joint function of patients with knee ligament injury. Methods One hundred and seventeen patients with knee ligament injury admitted to Xixi Hospital of Hangzhou from November 2018 to November 2021 were randomly divided into exercise group (38 cases), drug group (39 cases) and combined group (40 cases). The patients in exercise group were treated with exercise therapy, the patients in drug group were treated with celecoxib, and the patients in combined group were treated with celecoxib combined with exercise therapy. The clinical efficacy, adverse reactions, changes of joint swelling, pain, joint range of motion and function before and after treatment were compared among the three groups. Results After treatment, the swelling value and visual analogue scale (VAS) scores of the three groups were significantly lower than those of the group before treatment, the motion range of internal rotation, external rotation, flexion and extension were significantly higher than those of the group before treatment, and International Knee Documentation Committee (IKDC) and Lysholm scores were significantly higher than those of the group before treatment (P<0.05). The swelling value and VAS score of the patients in combined group were significantly lower than those in exercise group and drug group, while the motion range of internal rotation, external rotation, flexion and extension were significantly higher than those in exercise group and drug group, and the IKDC score and Lysholm score were significantly higher than those in exercise group and drug group (P<0.05). The total effective rate of combined group was significantly higher than that of exercise group and drug group (P<0.05). There was no significant difference in total incidence of adverse reactions among three groups (P>0.05). Conclusion Exercise therapy combined with celecoxib can significantly relieve the pain and swelling of patients with knee ligament injury, improve joint mobility and joint function, and promote the recovery of patients.
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