Abstract:Objective To explore the effect of exercise therapy combined with celecoxib on joint function of patients with knee ligament injury. Methods One hundred and seventeen patients with knee ligament injury admitted to Xixi Hospital of Hangzhou from November 2018 to November 2021 were randomly divided into exercise group (38 cases), drug group (39 cases) and combined group (40 cases). The patients in exercise group were treated with exercise therapy, the patients in drug group were treated with celecoxib, and the patients in combined group were treated with celecoxib combined with exercise therapy. The clinical efficacy, adverse reactions, changes of joint swelling, pain, joint range of motion and function before and after treatment were compared among the three groups. Results After treatment, the swelling value and visual analogue scale (VAS) scores of the three groups were significantly lower than those of the group before treatment, the motion range of internal rotation, external rotation, flexion and extension were significantly higher than those of the group before treatment, and International Knee Documentation Committee (IKDC) and Lysholm scores were significantly higher than those of the group before treatment (P<0.05). The swelling value and VAS score of the patients in combined group were significantly lower than those in exercise group and drug group, while the motion range of internal rotation, external rotation, flexion and extension were significantly higher than those in exercise group and drug group, and the IKDC score and Lysholm score were significantly higher than those in exercise group and drug group (P<0.05). The total effective rate of combined group was significantly higher than that of exercise group and drug group (P<0.05). There was no significant difference in total incidence of adverse reactions among three groups (P>0.05). Conclusion Exercise therapy combined with celecoxib can significantly relieve the pain and swelling of patients with knee ligament injury, improve joint mobility and joint function, and promote the recovery of patients. |