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血清CTRP13与妊娠糖尿病及妊娠结局的相关研究
Study on the relationship between serum CTRP13 and gestational diabetes mellitus and pregnancy outcome
收稿日期:  
DOI:10.3969/j.issn.1673-9701.2024.19.016
关键词:  妊娠糖尿病  CTRP13  糖脂代谢  不良妊娠结局
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作者单位
辛雅萍 郑州大学第二附属医院内分泌及代谢性疾病科河南郑州 450000 
马晓静 郑州大学第二附属医院内分泌及代谢性疾病科河南郑州 450000 
阮梦梦 郑州大学第二附属医院内分泌及代谢性疾病科河南郑州 450000 
张琦 郑州大学第二附属医院内分泌及代谢性疾病科河南郑州 450000 
宣艳 郑州大学第二附属医院内分泌及代谢性疾病科河南郑州 450000 
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摘要:目的 探讨补体C1q/肿瘤坏死因子相关蛋白13(C1q tumor necrosis factor related protein 13,CTRP13)与妊娠糖尿病(gestational diabetes mellitus,GDM)的关系及CTRP13对GDM孕妇不良妊娠结局的预测价值。方法 选取2023年1月至5月于郑州大学第二附属医院行产前检查的孕妇163例,根据孕24~28周口服葡萄糖耐量试验结果,将其分别纳入GDM组(n=83)和正常糖耐量(normal glucose tolerance,NGT)组(n=80)。收集两组孕妇的一般资料、生化资料、不良妊娠结局,分析GDM孕妇血清CTRP13与糖脂代谢指标的相关性。绘制受试者操作特征曲线(receiver operating characteristic curve,ROC曲线)分析CTRP13对GDM孕妇不良妊娠结局的预测价值。结果 GDM组孕妇的孕前体质量指数、产前体质量指数、三酰甘油、总胆固醇、低密度脂蛋白、空腹血糖、负荷后2h血糖、糖化血红蛋白、空腹胰岛素及稳态模型评估的胰岛素抵抗指数均显著高于NGT组,CTRP13显著低于NGT组(P<0.05)。血清CTRP13与GDM孕妇的总胆固醇、三酰甘油、低密度脂蛋白、负荷后2h血糖、糖化血红蛋白均呈负相关(P<0.05)。GDM组孕妇的妊娠高血压和胎膜早破的发生率均显著高于NGT组(P<0.05)。血清CTRP13预测GDM孕妇不良妊娠结局的曲线下面积为0.805,敏感度和特异性分别为75.80%、76.00%。结论 血清CTRP13与GDM孕妇的糖脂代谢有关,血清CTRP13是预测GDM孕妇不良妊娠结局的潜在生物标志物。
Abstract:Objective To explore the relationship between C1q tumor necrosis factor related protein 13 (CTRP13) and gestational diabetes mellitus (GDM), and the predictive value of CTRP13 for adverse pregnancy outcomes in GDM patients. Methods A total of 163 pregnant women who underwent prenatal examination in the Second Affiliated Hospital of Zhengzhou University from January to May 2023 were enrolled in GDM group (n=83) and normal glucose tolerance (NGT) group (n=80) according to the results of oral glucose tolerance test at 24-28 weeks of gestation. Collect general information, biochemical data, and adverse pregnancy outcomes from two groups of subjects. Analyze the correlation between serum CTRP13 and glucose and lipid metabolism indicators in GDM pregnant women. The receiver operating characteristic (ROC) curve was drawn to analyze the predictive value of CTRP13 for adverse pregnancy outcomes in GDM pregnant women. Results The pre pregnancy body mass index, prenatal body mass index, triglycerides, total cholesterol, low density lipoprotein, fasting blood glucose, 2-hours plasma glucose, glycosylated hemoglobin, fasting insulin, and homeostasis model assessment of insulin resistanc index in GDM group was significantly higher than those in NGT group, while CTRP13 was significantly lower than that in NGT group (P<0.05). Serum CTRP13 was negatively correlated with total cholesterol, triglycerides, low density lipoprotein, 2-hours plasma glucose, and glycosylated hemoglobin in GDM patients (P<0.05). The incidence of adverse pregnancy outcomes such as gestational hypertension and premature rupture of membranes in GDM group were significantly higher than those in NGT group (P<0.05). The area under the curve of serum CTRP13 for predicting adverse pregnancy outcomes in GDM pregnant women was 0.805, with sensitivity and specificity of 75.80% and 76.00%, respectively. Conclusion Serum CTRP13 is associated with glucose and lipid metabolism in GDM pregnant women, and is a potential biomarker for predicting adverse pregnancy outcomes in GDM pregnant women.
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